Endocrine Abstracts

European and world-wide obesity epidemic and continuously rising prevalence of obesity necessitates long-term efficient, economically bearable and patient safe solution. Bariatric surgery (surgery for obesity – different from lifestyle, body shaping surgery), is the most effective, low risk treatment modality for morbidly obese patients in terms of total weight loss and and long-term weight maintenance, currently available.It has to be stressed howe...

Aims/hypothesis: Genetic and functional defects in mitochondria are linked with phenotypes of obesity, hypercholesterolemia, and type 2 diabetes (T2DM). However, the impact on mitochondria during surgery-induced metabolic recovery is unknown. We therefore studied the effect of restrictive versus malabsorptive bariatric procedures on indicators of mitochondrial efficiency and control of biogenesis/function.Methods: Forty-three morbidly obese, T2DM consent...

Background and aims: Bariatric surgery can lead to a quick reversal in type 2 diabetes mellitus (T2DM) status. However, despite this reversal inflammatory responses may still persist via activation of Toll-like receptors (TLR) within adipose tissue (AT); with triglycerides (TGs) noted as a potential mediator of such inflammation. Therefore the aims of these studies were to understand the impact of TG changes, pre- and post-bariatric surgery, on TLR expression in ex vivo</e...

Background: In obesity, excess nutrients and an increased demand for protein synthesis contribute to unfolded proteins accumulating within the endoplasmic reticulum and consequent activation of unfolded protein response (UPR). UPR in adipose tissue (AT) is critical to the initiation and integration of inflammation and insulin signalling pathways in obese and type 2 diabetes mellitus (T2DM) patients. The aim of this study was to examine whether novel malabsorptive or bypass bar...